Temerty Faculty of Medicine / en Â鶹ֱ˛Ąapp community members recognized with Order of Canada /news/u-t-community-members-recognized-order-canada-2 <span class="field field--name-title field--type-string field--label-hidden">Â鶹ֱ˛Ąapp community members recognized with Order of Canada</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-12/gg05-2018-0316-001-crop.jpg?h=81d682ee&amp;itok=Cibnvyzb 370w, /sites/default/files/styles/news_banner_740/public/2024-12/gg05-2018-0316-001-crop.jpg?h=81d682ee&amp;itok=1Xt6KMvf 740w, /sites/default/files/styles/news_banner_1110/public/2024-12/gg05-2018-0316-001-crop.jpg?h=81d682ee&amp;itok=834gbPgo 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-12/gg05-2018-0316-001-crop.jpg?h=81d682ee&amp;itok=Cibnvyzb" alt="a display of the various order of canada medals and honours"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-12-19T11:01:38-05:00" title="Thursday, December 19, 2024 - 11:01" class="datetime">Thu, 12/19/2024 - 11:01</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>(photo by&nbsp;Sgt Johanie Maheu)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/adam-elliott-segal" hreflang="en">Adam Elliott Segal</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/lunenfeld-tanenbaum-research-institute" hreflang="en">Lunenfeld-Tanenbaum Research Institute</a></div> <div class="field__item"><a href="/news/tags/anthropology" hreflang="en">Anthropology</a></div> <div class="field__item"><a href="/news/tags/dalla-lana-school-public-health" hreflang="en">Dalla Lana School of Public Health</a></div> <div class="field__item"><a href="/news/tags/factor-inwentash-faculty-social-work" hreflang="en">Factor-Inwentash Faculty of Social Work</a></div> <div class="field__item"><a href="/news/tags/faculty-arts-science" hreflang="en">Faculty of Arts &amp; Science</a></div> <div class="field__item"><a href="/news/tags/faculty-dentistry" hreflang="en">Faculty of Dentistry</a></div> <div class="field__item"><a href="/news/tags/faculty-law" hreflang="en">Faculty of Law</a></div> <div class="field__item"><a href="/news/tags/hospital-sick-children" hreflang="en">Hospital for Sick Children</a></div> <div class="field__item"><a href="/news/tags/institute-medical-science" hreflang="en">Institute of Medical Science</a></div> <div class="field__item"><a href="/news/tags/laboratory-medicine-and-pathobiology" hreflang="en">Laboratory Medicine and Pathobiology</a></div> <div class="field__item"><a href="/news/tags/molecular-genetics" hreflang="en">Molecular Genetics</a></div> <div class="field__item"><a href="/news/tags/mount-sinai-hospital" hreflang="en">Mount Sinai Hospital</a></div> <div class="field__item"><a href="/news/tags/nutritional-sciences" hreflang="en">Nutritional Sciences</a></div> <div class="field__item"><a href="/news/tags/oise" hreflang="en">OISE</a></div> <div class="field__item"><a href="/news/tags/order-canada" hreflang="en">Order of Canada</a></div> <div class="field__item"><a href="/news/tags/political-science" hreflang="en">Political Science</a></div> <div class="field__item"><a href="/news/tags/trinity-college" hreflang="en">Trinity College</a></div> <div class="field__item"><a href="/news/tags/u-t-mississauga" hreflang="en">Â鶹ֱ˛Ąapp Mississauga</a></div> <div class="field__item"><a href="/news/tags/u-t-scarborough" hreflang="en">Â鶹ֱ˛Ąapp Scarborough</a></div> <div class="field__item"><a href="/news/tags/university-college" hreflang="en">University College</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">"Each in their own way, they broaden the realm of possibilities and inspire others to continue pushing its boundaries"</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A pediatric surgeon who pioneered techniques to keep children’s hearts pumping. An anthropologist whose work has explored how land development shapes communities. A leading mathematician also renowned for scholarship on Indian philosophy.</p> <p>These are a few of the University of Toronto community members who were recently recognized by the Order of Canada.</p> <p>The Governor General announced <a href="https://www.gg.ca/en/appointments-order-canada-december-2024">88 new appointments to the Order of Canada</a> on Dec 18, including three promotions. They include <strong>George Trusler</strong>, former head of cardiac surgery at the Hospital for Sick Children and a professor emeritus in the department of surgery in the Temerty Faculty of Medicine;&nbsp;<strong>Tania Li</strong>, a <a href="https://www.provost.utoronto.ca/awards-funding/university-professors/complete-list-university-professors/">University Professor</a> in the department of anthropology in the Faculty of Arts &amp; Science; and <strong>Vijaya Kumar Murty</strong>, a professor in the department of mathematics in the Faculty of Arts &amp; Science.</p> <p>“Members of the Order of Canada are builders of hope for a better future,” Gov. Gen.&nbsp;<strong>Mary Simon</strong>&nbsp;said <a href="https://www.gg.ca/en/media/news/2024/appointments-order-canada-december">in a statement</a>. “Each in their own way, they broaden the realm of possibilities and inspire others to continue pushing its boundaries.&nbsp;Thank you for your perseverance, fearless leadership and visionary spirit, and welcome to the Order of Canada.”&nbsp;</p> <p>Created in 1967, the Order of Canada is one of the country’s highest civilian honours. It recognizes individuals whose achievements and service have had an impact on communities across Canada and beyond.</p> <p>Here is a list of Â鶹ֱ˛Ąapp faculty, alumni, supporters and friends who were appointed to, or promoted within, the Order of Canada in the latest round:</p> <hr> <h3>Current and former faculty</h3> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/image001.jpg?itok=e99KyMHL" width="150" height="149" alt="Stephen Arshinoff" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Steve Arshinoff</strong>, a professor in the department of ophthalmology and vision sciences in the Temerty Faculty of Medicine, was named an Officer of the Order for his contributions to eye care, pioneering now-standard practices. Co-founder of the Eye Foundation of Canada, he also serves as a medical director of Eye Van, providing care to remote northern Ontario communities. He completed his ophthalmology residency at Â鶹ֱ˛Ąapp.&nbsp;<br> &nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/Sylvia_sml-crop.jpg?itok=IAiBIePq" width="150" height="150" alt="Sylvia Bashevkin" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Sylvia Bashevkin</strong>, a professor emerita in the department of political science in the Faculty of Arts &amp; Science, was named an Officer of the Order for her contributions as a leading scholar of gender and politics. A former principal of University College and a senior fellow of Massey College, she pioneered research on the barriers faced by women in public life and has worked to expand opportunities for diverse political engagement.&nbsp;&nbsp;<br> &nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/DrBhutta-crop.jpg?itok=TxbpQdI5" width="150" height="150" alt="Zulfiqar Bhutta" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Zulfiqar Bhutta</strong>, a professor in the department of nutritional sciences in the Temerty Faculty of Medicine, was named an Officer of the Order for his contributions as one of the world’s foremost authorities on maternal and child health, shaping public health strategies that have reduced mortality and improved the well-being of women and children worldwide.&nbsp;&nbsp;<br> <br> &nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/IMG_6664-copy.jpg?itok=9N9b7lbc" width="150" height="150" alt="Sandy Buchman" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Sandy Buchman</strong>, medical director of the Freeman Centre for the Advancement of Palliative Care at North York General Hospital and associate professor in the department of family and community medicine in the Temerty Faculty of Medicine, was named a Member of the Order for contributions to palliative medicine. A former president of the Canadian Medical Association, Buchman has advocated for palliative care, MAID and equitable access to compassionate care. He completed his residency in family medicine at Â鶹ֱ˛Ąapp.</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/10289_OFCPortraits_20221124-David-Chitayat-crop.jpg?itok=SI0qIS_S" width="150" height="150" alt="David Chitayat" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>David Chitayat</strong>, head of the prenatal diagnosis and medical genetics program at Mount Sinai Hospital, physician at SickKids and professor in the Temerty Faculty of Medicine’s departments of paediatrics, obstetrics and gynaecology, laboratory medicine and pathobiology, and molecular genetics, was named a Member of the Order for his globally acclaimed work identifying genes associated with fetal abnormalities and postnatal newborns.</p> <p><strong>Dafna Gladman</strong>, a senior scientist at the Toronto Western Research Institute and a professor in the Institute of Medical Science in the Temerty Faculty of Medicine, was named an Officer of the Order for her contributions to the psoriatic arthritis field. Her research advanced the understanding of the chronic disease, and her advocacy has improved the treatment and care. She earned her medical degree from Â鶹ֱ˛Ąapp.&nbsp;&nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/_Haas%2C-Dan-Portraits_2021-12-08_015-crop.jpg?itok=Qhmxjh8N" width="150" height="150" alt="Daniel Haas" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Daniel Haas</strong>,&nbsp;a professor and former dean of the Faculty of Dentistry, was appointed a Member of the Order for his expertise in dental anesthesiology and pharmacology. The former head of the faculty’s graduate dental anaesthesia speciality program, Haas has influenced dental training and practices worldwide. He earned his bachelor of science, doctor of dental surgery and PhD at Â鶹ֱ˛Ąapp.<br> &nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/UofT13192_t-li_7199-crop.jpg?itok=65UXsgm9" width="150" height="150" alt="Tania Li" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Tania Li</strong>, a <a href="https://www.provost.utoronto.ca/awards-funding/university-professors/complete-list-university-professors/">University Professor</a> in the department of anthropology in the Faculty of Arts &amp; Science, was named an Officer of the Order for her contributions as one of Canada’s leading anthropologists. Her research – including groundbreaking work in understanding how international land development and corporate agriculture generate unintended poverty – has had a profound interdisciplinary impact, shaping policy and advancing human rights and sustainability initiatives.</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/UofT85114_2020-03-30-Kumar-Murty-%2811%29-crop.jpg?itok=WkMsMDfz" width="150" height="150" alt="Vijayakumar Murty" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Vijaya Kumar Murty</strong>, a professor in the department of mathematics in the Faculty of Arts &amp; Science, was named a Member of the Order for his contributions as one of Canada’s leading mathematicians. A former director of the Fields Institute for Research in Mathematical Sciences at Â鶹ֱ˛Ąapp, he has advanced knowledge in various mathematical fields, including analytic number theory. He is also a renowned scholar of Indian philosophy. &nbsp;<br> &nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/09357_Greg_Ryan_0007-crop.jpg?itok=yVUl9vWj" width="150" height="150" alt="&quot;&quot;" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Greg Ryan</strong>, a perinatologist at Mount Sinai Hospital, head of the fetal medicine unit at Sinai Health and professor in the department of obstetrics and gynaecology in the Temerty Faculty of Medicine, was named a Member of the Order for his groundbreaking contributions to fetal medicine. A senior clinician scientist in the Lunenfeld-Tanenbaum Research Institute, he has revolutionized in-utero treatment and care, improving outcomes for mothers and their unborn children globally.&nbsp;</p> <div class="align-left"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_150_width_/public/2024-12/UofT84429_Valerie-Tarasuk_11-5-2019_by-Jim-Oldfield-crop.jpg?itok=MiODT-uG" width="150" height="150" alt="Valarie Tarasuk" class="image-style-scale-image-150-width-"> </div> </div> <p><strong>Valerie Sue Tarasuk</strong>, a professor emerita in the department of nutritional sciences in the Temerty Faculty of Medicine with a cross-appointment to the Dalla Lana School of Public Health, was named a Member of the Order for her expertise on food insecurity in Canada. Tarasuk has worked to reduce food insecurity with policy intervention through PROOF, an interdisciplinary research program. She earned her master of science and PhD at Â鶹ֱ˛Ąapp.&nbsp;&nbsp;  &nbsp;</p> <p><strong>George Trusler</strong>, former head of cardiac surgery at SickKids and a professor emeritus in the department of surgery in the Temerty Faculty of Medicine, was named an Officer of the Order in recognition of innovations in pediatric and cardiac surgery. His innovations have saved thousands of lives, including his &nbsp;groundbreaking invention to preserve the aortic valve and his design of an algorithm to control excess blood flow to the lungs of infants suffering heart failure.</p> <h3>Alumni and Friends</h3> <p><strong>J. Anthony Boeckh</strong>, who earned a bachelor of commerce in 1960 as a member of Trinity College, was named a Member of the Order in recognition of contributions to youth mental health through the Graham Boeckh Foundation, which he founded in honour of his late son. Boeckh has worked with leading global experts to establish strategies to transform Canada’s mental health care system. He is also a founding trustee of the Fraser Institute.</p> <p><strong>Stacy Churchill</strong>, a professor emeritus in the Ontario Institute for Studies in Education, was named a Member of the Order for her expertise in education and linguistic rights for Francophone minorities. Churchill has advised the federal and provincial government on language policy and consulted on UNICEF and UNESCO education missions.</p> <p><strong>Carol Cowan-Levine</strong>, who earned her master’s in social work from Â鶹ֱ˛Ąapp, was recognized with the Order of Canada for her leadership role in social work&nbsp;and the establishment of the College of Registered Psychotherapists of Ontario.&nbsp;Her extensive volunteer work has impacted government, health care institutions and the non-profit sector in Ontario.</p> <p><strong>Stan Douglas</strong>, a renowned multimedia artist, was named an Officer of the Order for his body of work that explores history, technology and memory. His work has been exhibited internationally, including at the 2022 Venice Biennale. His donated piece, Maritime Workers Hall, Vancouver, hangs in the halls of Â鶹ֱ˛Ąapp’s Hart House as part of the Hart House Permanent Collection.</p> <p><strong>Donald Dippo</strong>, who earned a master of education and PhD from Â鶹ֱ˛Ąapp, was named a Member of the Order for increasing educational access for children and teachers in Canada and internationally. He co-founded the Borderless Higher Education for Refugees program, based in the Dadaab refugee camps of Kenya.</p> <p><strong>R. Douglas Elliott</strong> was named a Member of the Order for his advancement and protection of 2SLGBTQI+ rights under Canadian law. An alumnus of the Faculty of Law, he has been involved in landmark constitutional cases and class actions, notably serving as lead counsel in the LGBT Purge class action.</p> <p><strong>Aura Kagan</strong>, a speech language pathologist who earned a PhD from Â鶹ֱ˛Ąapp, was named an Officer of the Order for contributions that profoundly shaped care for people living with aphasia&nbsp;–&nbsp;a disorder that disrupts the ability to speak, understand, read, and write&nbsp;– including groundbreaking methods to help individuals communicate more effectively.&nbsp;</p> <p><strong>Jeffrey J. McDonnell</strong>, who earned a bachelor of science from Â鶹ֱ˛Ąapp Scarborough in 1984, was named an Officer of the Order for his seminal scientific impact on the field of hydrology. A professor at the University of Saskatchewan, he has transformed the understanding of streamflow generation and the water cycle.</p> <p><strong>Maureen Jennings</strong>, who earned a master’s degree at Â鶹ֱ˛Ąapp in 1967, was named a Member of the Order for her achievements as an historical crime author, most notably for the creation of the <em>Detective Murdoch</em> series – which inspired the long-running TV show <em>Murdoch Mysteries</em> – and for her contributions to Canadian history regarding women's roles during the Second World War.</p> <p><strong>Karen Levine</strong>, who earned a bachelor of arts as a member of University College in 1977, was named a Member of the Order in recognition of her decades-long career at CBC Radio. She is also honoured for her book <em>Hana’s Suitcase</em>, which has educated young readers worldwide about the Holocaust.</p> <p><strong>Sam Shemie</strong>, who completed his pediatric cardiology fellowship at Â鶹ֱ˛Ąapp, was named a Member of the Order for shaping new ethical standards surrounding organ donation, creating new protocols for hospital culture and mentoring hundreds of clinical care physicians in Canada and abroad. He is medical director of the pediatric intensive care unit at Montreal Children's Hospital.</p> <p><strong>Walter Schneider</strong>, who earned a degree in literary arts from Â鶹ֱ˛Ąapp Mississauga, was named a Member of the Order for contributions to business, entrepreneurship and philanthropy. As president and co-founder of RE/MAX INTEGRA, he transformed Canadian real estate, building the company into the nation’s top-selling organization.</p> <p><em>– With files from Mariam Matti</em></p> <h3><a href="/news/tags/order-canada">Read about more Â鶹ֱ˛Ąapp community members recognized with the Order of Canada in recent years</a></h3> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Thu, 19 Dec 2024 16:01:38 +0000 rahul.kalvapalle 311073 at Researchers at Â鶹ֱ˛Ąapp, partner hospitals receive $35 million in provincial support  /news/researchers-u-t-partner-hospitals-receive-35-million-provincial-support <span class="field field--name-title field--type-string field--label-hidden">Researchers at Â鶹ֱ˛Ąapp, partner hospitals receive $35 million in provincial support&nbsp;</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-12/GettyImages-1449330889-crop.jpg?h=81d682ee&amp;itok=sbwKCn0m 370w, /sites/default/files/styles/news_banner_740/public/2024-12/GettyImages-1449330889-crop.jpg?h=81d682ee&amp;itok=QFxQAWPq 740w, /sites/default/files/styles/news_banner_1110/public/2024-12/GettyImages-1449330889-crop.jpg?h=81d682ee&amp;itok=jaarW-pD 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-12/GettyImages-1449330889-crop.jpg?h=81d682ee&amp;itok=sbwKCn0m" alt="EV cars charging in an underground lot"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>lanthierj</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-12-11T13:57:47-05:00" title="Wednesday, December 11, 2024 - 13:57" class="datetime">Wed, 12/11/2024 - 13:57</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>The performance of lithium ion batteries that power electric vehicles, like the ones plugged into these chargers, can be degraded by temperature fluctuations – a limitation researchers at Â鶹ֱ˛Ąapp Engineering are working to change (photo by&nbsp;koiguo/Getty Images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/tyler-irving" hreflang="en">Tyler Irving</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/institute-biomedical-engineering" hreflang="en">Institute of Biomedical Engineering</a></div> <div class="field__item"><a href="/news/tags/leah-cowen" hreflang="en">Leah Cowen</a></div> <div class="field__item"><a href="/news/tags/sinai-health" hreflang="en">Sinai Health</a></div> <div class="field__item"><a href="/taxonomy/term/6923" hreflang="en">Sunnybrook Health Sciences Centre</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/unity-health" hreflang="en">Unity Health</a></div> <div class="field__item"><a href="/news/tags/cell-and-systems-biology" hreflang="en">Cell and Systems Biology</a></div> <div class="field__item"><a href="/news/tags/anthropology" hreflang="en">Anthropology</a></div> <div class="field__item"><a href="/news/tags/astronomy-astrophysics" hreflang="en">Astronomy &amp; Astrophysics</a></div> <div class="field__item"><a href="/news/tags/biochemistry" hreflang="en">Biochemistry</a></div> <div class="field__item"><a href="/news/tags/centre-addiction-and-mental-health" hreflang="en">Centre for Addiction and Mental Health</a></div> <div class="field__item"><a href="/news/tags/chemistry" hreflang="en">Chemistry</a></div> <div class="field__item"><a href="/news/tags/computer-science" hreflang="en">Computer Science</a></div> <div class="field__item"><a href="/news/tags/dalla-lana-school-public-health" hreflang="en">Dalla Lana School of Public Health</a></div> <div class="field__item"><a href="/news/tags/ecology-and-evolutionary-biology" hreflang="en">Ecology and Evolutionary Biology</a></div> <div class="field__item"><a href="/news/tags/faculty-applied-science-engineering" hreflang="en">Faculty of Applied Science &amp; Engineering</a></div> <div class="field__item"><a href="/news/tags/faculty-arts-science" hreflang="en">Faculty of Arts &amp; Science</a></div> <div class="field__item"><a href="/news/tags/hospital-sick-children" hreflang="en">Hospital for Sick Children</a></div> <div class="field__item"><a href="/news/tags/laboratory-medicine-and-pathobiology" hreflang="en">Laboratory Medicine and Pathobiology</a></div> <div class="field__item"><a href="/news/tags/leslie-dan-faculty-pharmacy" hreflang="en">Leslie Dan Faculty of Pharmacy</a></div> <div class="field__item"><a href="/news/tags/mathematics" hreflang="en">Mathematics</a></div> <div class="field__item"><a href="/news/tags/physics" hreflang="en">Physics</a></div> <div class="field__item"><a href="/news/tags/psychology" hreflang="en">Psychology</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/university-health-network" hreflang="en">University Health Network</a></div> <div class="field__item"><a href="/news/tags/utias" hreflang="en">UTIAS</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">From better batteries to preventing memory loss, nearly four dozen projects at Â鶹ֱ˛Ąapp and its partner hospitals are being supported by the&nbsp;Ontario Research Fund </div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Researchers in the University of Toronto’s&nbsp;Thermal Management Systems (TMS) Laboratory&nbsp;are working to improve the way battery systems handle heat and develop structural battery pack components. &nbsp;</p> <p>“Whether they are being used for electric vehicles or for stationary energy storage systems that reduce strain on the grid, lithium-ion batteries are transforming the way we use electricity,” said <strong>Carlos Da Silva</strong>, senior research associate at the TMS Lab in the Faculty of Applied Science &amp; Engineering and executive director of Â鶹ֱ˛Ąapp’s <a href="https://electrification.utoronto.ca/">Electrification Hub</a>.&nbsp;</p> <p>“Unfortunately, today’s batteries are still sensitive to temperature: if they get too cold or too hot, it can degrade their performance and even present safety risks. We are working on new technologies that make batteries more resilient to thermal fluctuations.”&nbsp;</p> <p>The battery-related research is among nearly four dozen projects at Â鶹ֱ˛Ąapp and its partner hospitals that are receiving almost $35 million in support through the&nbsp;<a href="https://news.ontario.ca/en/release/1005382/ontario-investing-92-million-to-support-made-in-ontario-research-and-innovation">Ontario Research Fund – Research Excellence (ORF-RE) and the Ontario Research Fund – Small Infrastructure (ORF-SIF)</a>. (<a href="#list">See the full list of projects and their principal researchers below</a>).&nbsp;</p> <p>"Research at the University of Toronto and at all universities and colleges across Ontario is the foundation of the province’s competitiveness now and in the future,” said&nbsp;<strong>Leah Cowen</strong>, Â鶹ֱ˛Ąapp’s vice-president, research and innovation, and strategic initiatives.&nbsp;&nbsp;</p> <p>“This investment protects and advances cutting-edge, made-in-Ontario research in important economic sectors and helps ensure universities can continue to train, attract and retain the world’s top talent."&nbsp;</p> <p>At Â鶹ֱ˛Ąapp Engineering’s TMS Lab, researchers led by&nbsp;<strong>Cristina Amon</strong>, a&nbsp;<a href="https://www.provost.utoronto.ca/awards-funding/university-professors/">University Professor</a>&nbsp;in the department of mechanical and industrial engineering, are working on two funded projects. They are developing advanced computational modelling and digital twin methodologies that predict and optimize how heat flows through battery packs. The methodologies are carefully calibrated and validated through industry-relevant experiments in the lab.&nbsp;</p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-12/TMSlab-2--33_crop.jpg?itok=yj7xlK64" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>Senior Research Associate Carlos Da Silva, left, and University Professor Cristina Amon, right, chat in the Faculty of Applied Science &amp; Engineering's Thermal Management Systems Laboratory (photo by Aaron Demeter)</em></figcaption> </figure> <p>These methodologies will help battery designers anticipate and prevent thermal management challenges before they arise. It can also enable them to optimize the design and deployment of fire mitigation measures, such as ultra-thin heat barriers, within their battery systems.&nbsp;</p> <p>The team is also collaborating with Ford Canada and several other companies in the energy storage space. For example, they have worked with Jule (powered by eCAMION) on the development of direct current electric vehicle fast chargers with integrated battery energy storage systems, one of which was <a href="/news/battery-powered-ev-chargers-co-developed-u-t-installed-st-george-campus">recently unveiled on the Â鶹ֱ˛Ąapp campus</a>.&nbsp;</p> <p>“We are grateful for this ORF-RE funding, which will accelerate our research and help us further expand our partnerships, ensuring that battery thermal innovations have a seamless transition from the lab to the marketplace,” Amon said.&nbsp;</p> <p>“As a result of this work, the next generation of batteries will be safer and more resilient than ever before, which is especially important in colder climates like ours here in Ontario.” &nbsp;<a id="list" name="list"></a></p> <hr> <h4>Ontario Research Fund – Research Excellence:</h4> <ul> <li><a href="https://discover.research.utoronto.ca/13404-cristina-amon"><strong>Cristina Amon</strong></a>&nbsp;in the department of mechanical &amp; industrial engineering in the Faculty of Applied Science &amp; Engineering – <em>Powering Ontario’s grid transformation and electric vehicle fast charging with thermally resilient battery energy storage &amp; Next-gen electric vehicle battery systems: Lightweight, thermally performant and fire safe for all climates</em></li> <li><a href="https://discover.research.utoronto.ca/23353-morgan-barense"><strong>Morgan Barense</strong></a>&nbsp;in the&nbsp;department of psychology in the Faculty of Arts &amp; Science – <em>HippoCamera: Digital memory rehabilitation to combat memory loss</em></li> <li><a href="https://discover.research.utoronto.ca/21538-aimy-bazylak"><strong>Aimy Bazylak</strong></a>&nbsp;in the department of mechanical &amp; industrial engineering in the Faculty of Applied Science and Engineering – <em>RECYCLEAN: Critical minerals recycling &amp; re-manufacturing for the energy transition</em></li> <li><strong>Ian Connell</strong>&nbsp;at University Health Network and the department of medical biophysics in the Temerty Faculty of Medicine – <em>MRI-compatible innovations for neuromodulation</em></li> <li><strong>Simon Graham</strong>&nbsp;at Sunnybrook Health Sciences Centre and the department of medical biophysics in the Temerty Faculty of Medicine – <em>Technological innovations for clinical MRI of the brain at 7 tesla</em></li> <li><a href="https://discover.research.utoronto.ca/19009-clinton-groth"><strong>Clinton Groth</strong></a>&nbsp;in the Institute for Aerospace Studies in the Faculty of Applied Science &amp; Engineering – <em>Hydrogen as a sustainable aviation fuel – combustion research to remove impediments to adoption in gas turbine engines</em></li> <li><strong>James Kennedy&nbsp;</strong>at Centre for Addiction and Mental Health and the department of psychiatry in the Temerty Faculty of Medicine – <em>Clinical utility and enhancements of a pharmacogenomic decision support tool for mental health patients</em></li> <li><strong>Shaf Keshavjee</strong>&nbsp;at University Health Network and the department of surgery in the Temerty Faculty of Medicine – <em>Advanced solutions to human lung preservation and assessment using artificial intelligence</em></li> <li><strong>Aviad Levis</strong>&nbsp;in the department of computer science in the Faculty of Arts &amp; Science – <em>AI and quantum enhanced astronomy</em></li> <li><strong>JoAnne McLaurin</strong>&nbsp;at Sunnybrook Health Sciences Centre and the department of laboratory medicine &amp; pathobiology in the Temerty Faculty of Medicine – <em>Conversion of astrocytes to neurons to treat neurodegenerative diseases of the brain and the eye</em></li> <li><a href="https://discover.research.utoronto.ca/21310-r-j-dwayne-miller"><strong>R. J. Dwayne Miller</strong></a>&nbsp;in the department of chemistry in the Faculty of Arts &amp; Science – <em>PicoSecond InfraRed Laser (PIRL) “cancer knife” with complete biodiagnostics via spatial imaging mass spectrometry</em></li> <li><a href="https://discover.research.utoronto.ca/10412-javad-mostaghimi"><strong>Javad Mostaghimi</strong></a>&nbsp;in the department of mechanical &amp; industrial engineering in the Faculty of Applied Science &amp; Engineering – <em>A new generation of compact, transportable mass spectrometers for rapid, in-field sample analysi</em></li> <li><a href="https://discover.research.utoronto.ca/12421-shirley-xy-wu"><strong>Xiao Yu (Shirley) Wu</strong></a>&nbsp;in the Leslie Dan Faculty of Pharmacy – <em>Molecular dynamics modeling and screening of excipients for designing amorphous solid dispersion formulations of poorly–soluble drugs</em></li> </ul> <h4>Ontario Research Fund – Small Infrastructure Fund:</h4> <ul> <li><a href="https://discover.research.utoronto.ca/28945-celina-baines"><strong>Celina Baines</strong></a>&nbsp;in the department of ecology &amp; evolutionary biology in the Faculty of Arts &amp; Science –&nbsp;<em>Impacts of environmental change on organismal movement</em></li> <li><strong>Sergio de la Barrera</strong>&nbsp;in the department of physics in the Faculty of Arts &amp; Science –&nbsp;<em>Facility for quantum materials and device assembly from atomically thin van der Waals layers</em></li> <li><strong>Michelle Bendeck</strong>&nbsp;in the department of laboratory medicine &amp; pathobiology in the Temerty Faculty of Medicine –&nbsp;<em>4D quantitative cardiovascular physiology centre</em></li> <li><a href="https://discover.research.utoronto.ca/1070-laurent-bozec"><strong>Laurent Bozec</strong></a>&nbsp;in the department of laboratory medicine &amp; pathobiology in the Temerty Faculty of Medicine –&nbsp;<em>21st Century challenge for Dentistry: Breaking the cycle of irreversible dental tissue loss</em></li> <li><a href="https://discover.research.utoronto.ca/45747-mark-chiew"><strong>Mark Chiew</strong></a>&nbsp;at Sunnybrook Health Sciences Centre and the department of medical biophysics in the Temerty Faculty of Medicine –&nbsp;<em>Next generation computational MRI for rapid neuroimaging and image-guided therapy</em></li> <li><a href="https://discover.research.utoronto.ca/42705-haissi-cui"><strong>Haissi Cui</strong></a>&nbsp;in the department of chemistry in the Faculty of Arts &amp; Science –&nbsp;<em>A molecule to mouse approach to study the intracellular localization of genetic code interpretation in mammalian cells</em></li> <li><strong>Andy Kin On DeVeale</strong>&nbsp;at the University Health Network and the Dalla Lana School of Public Health –&nbsp;<em>Sarcopenia and musculoskeletal interactions (sami) collaborative hub</em></li> <li><strong>Ali Dolatabadi</strong>&nbsp;in the department of mechanical &amp; industrial engineering in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Advanced cold spray facility</em></li> <li><strong>Spencer Freeman</strong>&nbsp;at the Hospital for Sick Children and the department of biochemistry in the Temerty Faculty of Medicine –&nbsp;<em>Imaging biophysical determinants of the innate immune response</em></li> <li><strong>Liisa Galea</strong>&nbsp;at the Centre for Addiction and Mental Health and the Institute of Medical Science in the Temerty Faculty of Medicine –&nbsp;<em>Sex and sex-specific factors influencing brain health across the lifespan</em></li> <li><a href="https://discover.research.utoronto.ca/5658-maged-goubran"><strong>Maged Goubran</strong></a>&nbsp;at Sunnybrook Health Sciences Centre and the department of medical biophysics in the Temerty Faculty of Medicine –&nbsp;<em>AI platform for mapping, tracking and predicting circuit alterations in Alzheimer’s disease</em></li> <li><strong>Eitan Grinspun</strong>&nbsp;in the departments of computer science and department of mathematics in the Faculty of Arts &amp; Science –&nbsp;<em>A computer graphics perspective on entanglement of slender structures</em></li> <li><strong>Levon Halabelian</strong>&nbsp;in the Department of Pharmacology and Toxicology in the Temerty Faculty of Medicine –&nbsp;<em>Enabling a high-throughput drug discovery pipeline for targeting disease-related human proteins</em></li> <li><strong>Ziqing Hong</strong>&nbsp;in the department of physics in the Faculty of Arts &amp; Science –&nbsp;<em>Ultra-sensitive cryogenic detector development for dark matter and neutrino experiments&nbsp;</em></li> <li><strong>Eno Hysi</strong>&nbsp;at the Unity Health Toronto and the department of medical biophysics in the Temerty Faculty of Medicine –&nbsp;<em>Structural and functional assessments of diabetic skin microvasculature using photoacoustic imaging</em></li> <li><a href="https://discover.research.utoronto.ca/6634-lewis-kay"><strong>Lewis Kay</strong></a>&nbsp;in the department of biochemistry in the Temerty Faculty of Medicine – <em>Helium recovery system for the biomolecular NMR facility</em></li> <li><strong>Xiang Li&nbsp;</strong>in the department of chemistry and the department of physic in the Faculty of Arts &amp; Science –&nbsp;<em>Real-time multi-faceted probes of quantum materials</em></li> <li><strong>Qian Lin</strong>&nbsp;in the department of cell &amp; systems biology in the Faculty of Arts &amp; Science –&nbsp;<em>2p-RAM for whole-brain single-neuron imaging of behaving zebrafish to study neural mechanisms of cognitive behaviours</em></li> <li><a href="https://discover.research.utoronto.ca/34676-xilin-liu"><strong>Xilin Liu</strong></a>&nbsp;in the Edward S. Rogers Sr. department of electrical and computer engineering in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Integrated circuits for wireless brain implants with multi-modal neural interfaces</em></li> <li><strong>Stephen Lye</strong>&nbsp;at the Sinai Health System and the department of physiology in the Temerty Faculty of Medicine –&nbsp;<em>Healthy Life Trajectories Initiative (HeLTI) analytics platform</em></li> <li><a href="https://discover.research.utoronto.ca/52975-caitlin-maikawa"><strong>Caitlin Maikawa</strong></a>&nbsp;in the Institute of Biomedical Engineering in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Biointerfacing&nbsp;materials for drug delivery lab</em></li> <li><a href="https://discover.research.utoronto.ca/6448-emma-master"><strong>Emma Master</strong></a>&nbsp;in the department of chemical engineering &amp; applied chemistry in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Accelerating biomanufacturing innovation through enhanced capacity for scale-up and downstream bioprocess engineering</em></li> <li><strong>Roman Melnyk</strong>&nbsp;at the Hospital for Sick Children and the department of biochemistry in the Temerty Faculty of Medicine –&nbsp;<em>The H-SCREEN: A platform for high throughput and high content imaging-based small molecule screens for disease modulation</em></li> <li><strong>Juan Mena-Parra</strong>&nbsp;in the department of astronomy &amp; astrophysics in the Faculty of Arts &amp; Science –&nbsp;<em>An advanced laboratory to enable novel radio telescopes for cosmology and time-domain astrophysics</em></li> <li><strong>Seyed Mohamad Moosavi</strong>&nbsp;in the department of chemical engineering and applied chemistry in the Faculty of Applied Science &amp; Engineering –<em>&nbsp;Machine learning for nanoporous materials design</em></li> <li><strong>Enid Montague</strong>&nbsp;in the department of mechanical &amp; industrial engineering in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Automation and equity in healthcare laboratory</em></li> <li><strong>Michael Norris</strong>&nbsp;in the department of biochemistry in the Temerty Faculty of Medicine –&nbsp;<em>Infrastructure for structural and functional virology research hub</em></li> <li><a href="https://discover.research.utoronto.ca/18432-amaya-perezbrumer"><strong>Amaya Perez-Brumer</strong></a>&nbsp;in the Dalla Lana School of Public Health –&nbsp;<em>3P lab: Centering power, privilege and positionality for health equity research</em></li> <li><strong>Monica Ramsey</strong>&nbsp;in the department of anthropology at the University of Toronto Mississauga –&nbsp;<em>Ramsey Laboratory for Environmental Archaeology (RLEA): How human-environment interactions shaped plant-food</em></li> <li><strong>Arneet Saltzman</strong>&nbsp;in the department of cell &amp; systems biology in the in the Faculty of Arts &amp; Science –&nbsp;<em>Heterochromatin regulation in development and inheritance</em></li> <li><a href="https://discover.research.utoronto.ca/13279-mina-tadrous"><strong>Mina Tadrous</strong></a>&nbsp;in the Leslie Dan Faculty of Pharmacy –&nbsp;<em>Developing a centre for real-world evidence to improve the use of medications for Canadians</em></li> <li><a href="https://discover.research.utoronto.ca/25515-shurui-zhou"><strong>Shurui Zhou</strong></a>&nbsp;in the department of electrical &amp; computer engineering in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Improving collaboration efficiency for fork-based software development</em></li> <li><strong>Olena Zhulyn</strong>&nbsp;at the Hospital for Sick Children and the department of molecular genetics in the Temerty Faculty of Medicine –&nbsp;<em>Targeting translation for tissue regeneration and repair</em></li> <li><strong>Christoph Zrenner</strong>&nbsp;at the Centre for Addiction and Mental Health and the Institute of Biomedical Engineering in the Faculty of Applied Science &amp; Engineering –&nbsp;<em>Next-generation real-time closed-loop personalized neurostimulation</em></li> </ul> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Wed, 11 Dec 2024 18:57:47 +0000 lanthierj 310908 at Should you eat soy after menopause? Â鶹ֱ˛Ąapp researchers dispel myth about soy and cancer /news/should-you-eat-soy-after-menopause-u-t-researchers-dispel-myth-about-soy-and-cancer <span class="field field--name-title field--type-string field--label-hidden">Should you eat soy after menopause? Â鶹ֱ˛Ąapp researchers dispel myth about soy and cancer</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-12/GettyImages-1351412777-crop.jpg?h=81d682ee&amp;itok=2JvXY3iA 370w, /sites/default/files/styles/news_banner_740/public/2024-12/GettyImages-1351412777-crop.jpg?h=81d682ee&amp;itok=bYKNmtR2 740w, /sites/default/files/styles/news_banner_1110/public/2024-12/GettyImages-1351412777-crop.jpg?h=81d682ee&amp;itok=Pcv8Bks6 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-12/GettyImages-1351412777-crop.jpg?h=81d682ee&amp;itok=2JvXY3iA" alt="older asian woman eating a tofu salad"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-12-03T19:53:18-05:00" title="Tuesday, December 3, 2024 - 19:53" class="datetime">Tue, 12/03/2024 - 19:53</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>A study led by researchers at the Temerty Faculty of Medicine's department of nutritional sciences found that soy isoflavones – estrogen-like compounds – had no effect on key markers of estrogen-related cancers (photo by Yagi Studio/Getty Images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/betty-zou" hreflang="en">Betty Zou</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/unity-health" hreflang="en">Unity Health</a></div> <div class="field__item"><a href="/news/tags/nutritional-sciences" hreflang="en">Nutritional Sciences</a></div> <div class="field__item"><a href="/news/tags/st-michael-s-hospital" hreflang="en">St. Michael's Hospital</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">“We hope our study will help people feel more comfortable including soy foods in their diet"</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A study led by experts at the University of Toronto's Temerty Faculty of Medicine is providing reassuring evidence on consumption of soy foods during postmenopause.</p> <p>In a systematic review and meta-analysis of 40 trials in over 3,000 participants, Â鶹ֱ˛Ąapp researchers gathered results on the effects of soy isoflavones – estrogen-like compounds naturally found in plants – on biological outcomes related to risk of endometrial and other female-related cancers.</p> <p>Their results, published in&nbsp;<a href="https://www.sciencedirect.com/science/article/pii/S2161831324001613?via%3Dihub"><em>Advances in Nutrition</em></a>, found that isoflavones had no effect on key markers of estrogen-related cancers, supporting the safety of soy as a food as well as potential therapy.</p> <p>“The risk of cardiovascular disease increases substantially as women* go through menopause, so soy can offer dual benefits during this particular phase of life,” says the study’s senior author&nbsp;<strong>Laura Chiavaroli</strong>, an assistant professor in Temerty's department of nutritional sciences and affiliate scientist at the Li Ka Shing Knowledge Institute at St. Michael’s Hospital, Unity Health Toronto.</p> <figure role="group" class="caption caption-drupal-media align-left"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/2024-12/Chiavaroli_Viscardi-crop.jpg" width="350" height="228" alt="&quot;"> </div> </div> <figcaption><em>Assistant Professor Laura Chiavaroli (left) and PhD student Gabrielle Viscardi (supplied images)</em></figcaption> </figure> <p>Yet, Chiavaroli notes many people are hesitant to eat soy foods because they contain isoflavones, which have a similar structure to estrogen. In animal studies, large doses of isoflavones have been linked to a higher risk of cancer.</p> <p>“Something we hear very often is that people have a lot of concern about consuming soy because there are so many conflicting messages out there,” says&nbsp;<strong>Gabrielle Viscardi</strong>, a second-year PhD student in the department of nutritional sciences and the study’s lead author.</p> <p>This is despite the fact that several health advocacy groups, including the Canadian Cardiovascular Society, already recommend soy foods as part of a healthy diet. Health Canada and the U.S. Food and Drug Administration have both recognized soy&nbsp;– a high-quality and complete source of protein – as effective in reducing the risk of heart disease</p> <p>Soy foods have also been shown to alleviate hot flashes associated with menopause, which affect many women and impact their quality of life.</p> <p>The trials considered for the Â鶹ֱ˛Ąapp study followed postmenopausal women from around the world who had consumed either soy isoflavones or a non-isoflavone control for at least three months.</p> <p>The researchers concluded that consumption of soy isoflavones did not affect the four key estrogen-related markers, namely: thickness of uterus lining, vaginal maturation index (a measure of estrogen status) and levels of circulating estrogen and follicle-stimulating hormone.</p> <p>Their findings support the idea that soy isoflavones behave differently from human estrogen, particularly when it comes to cancers that depend on estrogen to develop. “We have estrogen receptors throughout our bodies but, contrary to the hormone estrogen, isoflavones from soy don’t bind to all the estrogen receptors equally,” says Viscardi, who is also a registered dietitian. “That’s why we see a beneficial effect on the cardiovascular system and no effect on the female reproductive system.”</p> <p>This difference in biological activity explains why soy isoflavones have been considered as a possible alternative to hormone replacement therapy (HRT), which is used to treat menopause symptoms by replacing the estrogen that the body stops producing during this period.</p> <p>Chiavaroli notes some people don’t want to take HRTs and are seeking alternative options.</p> <p>Further, HRTs may also not be a good option for people at an increased risk of estrogen-sensitive cancers like breast cancer, as well as those with a history of heart disease and stroke. For these individuals, consuming soy foods as part of a balanced diet could help manage their menopausal symptoms while also reducing the risk of cardiovascular disease.</p> <p>Chiavaroli says the study's findings also align with Health Canada’s dietary guidelines that encourage people to choose plant-based proteins more often, a move that would also convey benefits for the environment.</p> <p>“We hope our study will help people feel more comfortable including soy foods in their diet without being concerned that it’s going to increase their risk of estrogen-dependent cancer,” says Chiavaroli.</p> <p>The study was funded by the United Soybean Board (U.S. Department of Agriculture) and the Canadian Institutes of Health Research through the Canada-wide Human Nutrition Trialists’ Network.</p> <p><em>* Although menopause is sex-specific, the study retains use of the term "women" as it is used conventionally in studies and guidelines on menopause</em></p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Wed, 04 Dec 2024 00:53:18 +0000 rahul.kalvapalle 310855 at Â鶹ֱ˛Ąapp and Blue Jays sports doc on serving as Taylor Swift's primary care physician in Toronto /news/u-t-and-blue-jays-sports-doc-serving-taylor-swift-s-primary-care-physician-toronto <span class="field field--name-title field--type-string field--label-hidden">Â鶹ֱ˛Ąapp and Blue Jays sports doc on serving as Taylor Swift's primary care physician in Toronto</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-11/david-lawrence-and-wife-at-taylor-swift-concert-crop.jpg?h=81d682ee&amp;itok=_okmDt-D 370w, /sites/default/files/styles/news_banner_740/public/2024-11/david-lawrence-and-wife-at-taylor-swift-concert-crop.jpg?h=81d682ee&amp;itok=mr50mU5t 740w, /sites/default/files/styles/news_banner_1110/public/2024-11/david-lawrence-and-wife-at-taylor-swift-concert-crop.jpg?h=81d682ee&amp;itok=lcT2dalG 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-11/david-lawrence-and-wife-at-taylor-swift-concert-crop.jpg?h=81d682ee&amp;itok=_okmDt-D" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-12-02T09:20:45-05:00" title="Monday, December 2, 2024 - 09:20" class="datetime">Mon, 12/02/2024 - 09:20</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>David Lawrence, medical director and staff physician at Â鶹ֱ˛Ąapp's David L. MacIntosh Sport Medicine Clinic and assistant professor in the Temerty Faculty of Medicine, attends a Taylor Swift concert in Toronto with his wife (photo courtesy of David Lawrence)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jelena-damjanovic" hreflang="en">Jelena Damjanovic</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/city-culture" hreflang="en">City &amp; Culture</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/faculty-kinesiology-physical-education" hreflang="en">Faculty of Kinesiology &amp; Physical Education</a></div> <div class="field__item"><a href="/news/tags/music" hreflang="en">Music</a></div> <div class="field__item"><a href="/news/tags/toronto-blue-jays" hreflang="en">Toronto Blue Jays</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">David Lawrence says the physical and mental demands on Swift are comparable to those of elite athletes</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>David Lawrence&nbsp;</strong>is used to ensuring that high-level&nbsp;performers are healthy and ready to deliver on the big stage.&nbsp;A staff physician and medical director of the University of Toronto’s <a href="https://kpe.utoronto.ca/david-l-macintosh-sport-medicine-clinic">David L. MacIntosh Sport Medicine Clinic</a>, Lawrence is also lead team primary care physician for the Toronto Blue Jays.</p> <p>So when the opportunity arose to serve as primary care medical doctor for <strong>Taylor Swift</strong> during the Toronto stop of her Eras Tour, he approached it like he would caring for high-level athletes and teams.</p> <p>“Just like in an athletic team, the focus was on ensuring the health and readiness of a high-performing individual – in this case, Taylor Swift – along with her core team and supporting personnel,” says Lawrence, who is also an assistant professor in the Temerty Faculty of Medicine’s department of family and community medicine.&nbsp;“The physical and mental demands on her as an artist are comparable to those of elite athletes, with grueling schedules, significant physical exertion and the pressure to perform at peak levels.”</p> <p>Lawrence was approached by senior front office members of the Rogers Centre and Blue Jays organization for the job. “It’s fairly common for high-profile artists to reach out to local professional sports teams for logistical or medical support during large events,” he says.</p> <p>His role: provide primary care services on-call for Swift, her crew, support staff, family members and even children traveling with her team.</p> <p>He says the dynamic of working with a large, well-organized team behind the scenes felt familiar.&nbsp;“Crew members, much like the staff supporting athletes, often face their own physical and mental stresses,” he says. “The overarching goal in both scenarios is the same: to address any issues quickly and efficiently so the performance, whether on stage or on the field, can continue seamlessly.</p> <p>“The pressure to ensure readiness and a rapid return to performance if anything arose was another parallel, making this experience feel very much in line with my usual work.”</p> <p>While Lawrence wouldn’t have called himself a Swiftie before this experience, he says he was incredibly impressed by the pop star’s performances.&nbsp;“The production was staggering and Taylor’s ability to perform for over three straight hours was nothing short of remarkable, making it clear how much preparation and effort go into delivering a show of that calibre,” says Lawrence. “It was a true showcase of an incredible combination of talent and hard work.&nbsp;It gave me a whole new appreciation for the dedication and effort behind such performances.”</p> <p>Lawrence was also struck by the passion of Swift’s adoring fans.</p> <p>“It was like nothing I’ve ever seen before,” he says. “The energy in the crowd was electric. With everyone singing every lyric so passionately it felt like the audience was just as much a part of the performance.”</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Mon, 02 Dec 2024 14:20:45 +0000 Christopher.Sorensen 310810 at Â鶹ֱ˛Ąapp shines a spotlight on exceptional educators at Excellence in Teaching reception /news/u-t-shines-spotlight-exceptional-educators-excellence-teaching-reception <span class="field field--name-title field--type-string field--label-hidden">Â鶹ֱ˛Ąapp shines a spotlight on exceptional educators at Excellence in Teaching reception</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-9-CROP.jpg?h=81d682ee&amp;itok=cI-2VkXz 370w, /sites/default/files/styles/news_banner_740/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-9-CROP.jpg?h=81d682ee&amp;itok=1Oa10HYI 740w, /sites/default/files/styles/news_banner_1110/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-9-CROP.jpg?h=81d682ee&amp;itok=bQoimwph 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-9-CROP.jpg?h=81d682ee&amp;itok=cI-2VkXz" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-11-27T13:02:53-05:00" title="Wednesday, November 27, 2024 - 13:02" class="datetime">Wed, 11/27/2024 - 13:02</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><i>Â鶹ֱ˛Ąapp Vice-President and Provost Trevor Young (centre) poses with Cheryl Regehr Early Career Teaching Award recipients, from left to right: Jasty Singh, Spyridon Kotsovilis, S. Trimble and Roberta K. Timothy (photo by Polina Teif)</i></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/rahul-kalvapalle" hreflang="en">Rahul Kalvapalle</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/trevor-young" hreflang="en">Trevor Young</a></div> <div class="field__item"><a href="/news/tags/early-career-teaching-award" hreflang="en">Early Career Teaching Award</a></div> <div class="field__item"><a href="/news/tags/dalla-lana-school-public-health" hreflang="en">Dalla Lana School of Public Health</a></div> <div class="field__item"><a href="/news/tags/faculty-applied-science-engineering" hreflang="en">Faculty of Applied Science &amp; Engineering</a></div> <div class="field__item"><a href="/news/tags/faculty-arts-science" hreflang="en">Faculty of Arts &amp; Science</a></div> <div class="field__item"><a href="/news/tags/teaching" hreflang="en">Teaching</a></div> <div class="field__item"><a href="/news/tags/u-t-mississauga" hreflang="en">Â鶹ֱ˛Ąapp Mississauga</a></div> <div class="field__item"><a href="/news/tags/u-t-scarborough" hreflang="en">Â鶹ֱ˛Ąapp Scarborough</a></div> <div class="field__item"><a href="/news/tags/women-and-gender-studies" hreflang="en">Women and Gender Studies</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>At the University of Toronto, teaching is about much more than just imparting knowledge – it’s an engaging, dynamic and creative process that expands and enriches the way students think, preparing them for future success in academics and their careers.</p> <p>The recent Excellence in Teaching reception hosted by Â鶹ֱ˛Ąapp’s Office of the Provost&nbsp;recognized the fundamental importance of teaching to the university’s mission. In particular, it&nbsp;honoured five faculty members who received&nbsp;<a href="https://www.provost.utoronto.ca/awards-funding/university-of-toronto-early-career-teaching-award/#section_0">Cheryl Regehr Early Career Teaching Awards</a>, which were recently renamed in honour of <strong>Cheryl Regehr</strong> – Young’s <a href="/news/incredible-leadership-u-t-provost-cheryl-regehr-leaves-enduring-legacy">predecessor as vice-president and provost</a>, a professor in the Factor-Inwentash Faculty of Social Work and a longtime champion of teaching excellence and innovation at Â鶹ֱ˛Ąapp.</p> <p>“These awards recognize burgeoning talent among our most junior faculty. We expect – and we know from experience – that these recipients will continue to lead and excel in teaching,” <strong>Trevor Young</strong>, Â鶹ֱ˛Ąapp’s vice-president and provost said at the Nov. 4 event held at the Faculty Club.</p> <p>The event also featured the presentation of the <a href="https://www.provost.utoronto.ca/awards-funding/university-of-toronto-global-educator-award/">Global Educator Award</a>, which recognizes a faculty member who exemplifies Â鶹ֱ˛Ąapp’s global mission by incorporating intercultural and international perspectives.</p> <p>“I’m extremely proud of Â鶹ֱ˛Ąapp for many reasons,” Young said, “and one of them is what’s evident here today, which is the immense talent and experience of our faculty as well as their deep commitment to our university, to our students, to knowledge [and] to research. All that you’re doing is really incredible.”</p> <p><em>Â鶹ֱ˛Ąapp News</em> spoke with all six award winners about their approach to educating students:</p> <hr> <h3>Spyridon Kotsovilis</h3> <p><em>Assistant professor, teaching stream – department of political science, Â鶹ֱ˛Ąapp Mississauga</em></p> <p><em>Cheryl Regehr Early Career Teaching Award</em></p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-4-CROP.jpg?itok=5qPk70Bo" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>(photo by Polina Teif)</em></figcaption> </figure> <p>“I design and conduct my classes so that they engage, motivate and empower our students to connect and interact with the material and their peers in inclusive and respectful ways towards learning and achieving their academic goals.</p> <p>“I feel honoured and humbled by the recognition; as teaching is a collective effort, it also belongs to all those who make it possible&nbsp;–&nbsp;from the administration, to the division, to my department and colleagues, to staff across different units, centres and libraries, to the campus maintenance personnel. Ultimately, this is about our students, and I would like to accept this award on behalf of them.”</p> <h3>Alison Olechowski</h3> <p><em>Associate professor – department of mechanical and industrial engineering and Institute for Studies in Transdisciplinary Engineering and Practice (ISTEP), Faculty of Applied Science &amp; Engineering</em></p> <p><em>Cheryl Regehr Early Career Teaching Award</em></p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-11/0S1A1430-crop.jpg?itok=hq7GULrT" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>(photo by Liz Do)</em></figcaption> </figure> <p>“I’m very proud to receive this recognition for my teaching – I believe that teaching is a major channel through which I can have impact in my career, and so I strive to do it well. In my teaching I aim to bring the course content to life, so that my students can understand why they’re learning what they’re learning, and how it connects to the real world and their futures.”</p> <h3>Jasty Singh</h3> <p><em>Associate professor, teaching stream – department of immunology, Temerty Faculty of Medicine</em></p> <p><em>Cheryl Regehr Early Career Teaching Award</em></p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-5-CROP.jpg?itok=p11tDS0S" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>(photo by Polina Teif)</em></figcaption> </figure> <p>“My approach to teaching is heavily influenced by my own experiences as an undergraduate student, and subsequently a graduate student and postdoctoral fellow at the University of Toronto. I’ve always believed that learning happens everywhere –&nbsp;not just in the classroom. My goal is to create inclusive and engaging learning atmospheres that foster personal connections, encourage interdisciplinary exploration and promote ongoing intellectual curiosity.</p> <p>“Receiving this recognition was both an exciting and a deeply validating experience for me – I see it as a reflection of the collaborative efforts of our administrative and teaching support staff, teaching assistants, colleagues and students in the department of immunology.”</p> <h3>Roberta K. Timothy</h3> <p><em>Assistant professor, teaching stream – Dalla Lana School of Public Health</em></p> <p><em>Cheryl Regehr Early Career Teaching Award</em></p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-3-CROP.jpg?itok=iiC8L9ub" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>(photo by Polina Teif)</em></figcaption> </figure> <p>“I am extremely moved and honoured to be recognized for my teaching, particularly for the work I have dedicated my life to – intersectional, decolonizing, anti-racist, anti-oppression praxis, focusing on Black health and intentionally marginalized populations.&nbsp;</p> <p>“I believe that teaching is one of the most powerful mechanisms to create critical social justice learning and unlearning through creative and actionable change. My teaching is influenced by my over 30 years in community health and activism. It is ancestrally anointed and community led. My hope is that the next generations can continue to create systems and practices that provide healing and wellness for African/Black populations, and that public health can work in solidarity with empathy and deep respect for our health issues and outcomes.”</p> <h3>S. Trimble</h3> <p><em>Assistant professor, teaching stream – Women &amp; Gender Studies Institute, Faculty of Arts &amp; Science</em></p> <p><em>Cheryl Regehr Early Career Teaching Award</em></p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-6-CROP.jpg?itok=Q3lxwGbS" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>(photo by Polina Teif)</em></figcaption> </figure> <p>“As a teacher I always try to meet students where they are and unlock new ways of connecting with them. To do this, I’ve had to learn to be more vulnerable and playful in and beyond the classroom. This award is a welcome affirmation of my belief that play, creativity and community building are crucial components of teaching excellence.”</p> <h3>Phani Radhakrishnan</h3> <p><em>Associate professor, teaching stream – department of management, Â鶹ֱ˛Ąapp Scarborough</em></p> <p><em>Global Educator Award</em></p> <figure role="group" class="caption caption-drupal-media align-center"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/scale_image_750_width_/public/2024-11/2024-11-04-Excellence-in-teaching_Polina-Teif-2-crop-.jpg?itok=v4d5Y-iB" width="750" height="500" alt="&quot;&quot;" class="image-style-scale-image-750-width-"> </div> </div> <figcaption><em>(photo by Polina Teif)</em></figcaption> </figure> <p>“I did not expect in my humblest dreams to receive the Global Educator Award from Â鶹ֱ˛Ąapp. I&nbsp;grew up in Hyderabad, India, a big city that instills openness to different cultures.&nbsp;I encourage my domestic and international students at the University of Toronto to be open-minded when doing business in a multi-cultural environment.&nbsp;My goal is to instill a global and sustainable mindset in my students.”</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Wed, 27 Nov 2024 18:02:53 +0000 rahul.kalvapalle 310652 at To treat glioblastoma, researchers focus on tumour vulnerabilities /news/treat-glioblastoma-researchers-focus-tumour-vulnerabilities <span class="field field--name-title field--type-string field--label-hidden">To treat glioblastoma, researchers focus on tumour vulnerabilities </span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-11/MacLeod_Molaei_Angers.jpg?h=81d682ee&amp;itok=BLienvV3 370w, /sites/default/files/styles/news_banner_740/public/2024-11/MacLeod_Molaei_Angers.jpg?h=81d682ee&amp;itok=lXoe9VbV 740w, /sites/default/files/styles/news_banner_1110/public/2024-11/MacLeod_Molaei_Angers.jpg?h=81d682ee&amp;itok=npsUK_9z 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-11/MacLeod_Molaei_Angers.jpg?h=81d682ee&amp;itok=BLienvV3" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-11-21T09:21:00-05:00" title="Thursday, November 21, 2024 - 09:21" class="datetime">Thu, 11/21/2024 - 09:21</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>From left to right: researchers Graham MacLeod, Fatemeh Molaei and StĂ©phane Angers, director of Â鶹ֱ˛Ąapp’s&nbsp;Donnelly Centre for Cellular and Biomolecular Research (supplied images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/anika-hazra" hreflang="en">Anika Hazra</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/donnelly-centre-cellular-biomolecular-research" hreflang="en">Donnelly Centre for Cellular &amp; Biomolecular Research</a></div> <div class="field__item"><a href="/news/tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">"Our study increases our understanding of this type of cancer and proposes a different approach to treating it that will hopefully improve the prognosis of patients"</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A team led by researchers at the University of Toronto has uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer.</p> <p>The targets were identified through a screen for genetic vulnerabilities in patient-derived cancer stem cells that represent the variability found in tumours.</p> <p>The study was&nbsp;<a href="https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-23-4024/747393/Fitness-Screens-Map-State-Specific-Glioblastoma">published recently in the journal&nbsp;<em>Cancer Research</em></a>.</p> <p>“Glioblastoma tumors have evaded treatment thus far because their composition is highly variable both within and between tumours,” said&nbsp;<strong>Graham MacLeod</strong>, co-first author on the study and senior research associate at Â鶹ֱ˛Ąapp’s&nbsp;Donnelly Centre for Cellular and Biomolecular Research.</p> <p>“The tumours&nbsp;vary quite a bit from person to person, and even within a single tumour there are multiple cell types that harbour differences at the genetic level.”</p> <p>Glioblastoma is the most common type of brain cancer in adults. It is also the most challenging to treat due to the resistance of glioblastoma cancer stem cells, from which tumours grow, to therapy. Cancer stem cells that survive after a tumour is treated go on to form new tumours that do not respond to further treatment.</p> <p>A key finding of the research is that the variability among glioblastoma cancer stem cells can be observed across a gradient between two cell subtypes. On one end is the developmental subtype, which resembles cells in which normal neurodevelopment has gone awry. On the other is the injury-response subtype, which is an inflammatory state. The aim of the study was to identify potential treatment methods to target each subtype, thereby tackling tumours in a more holistic manner.</p> <p>This study follows&nbsp;<a href="https://www.sciencedirect.com/science/article/pii/S2211124719303638" target="_blank">earlier research published in&nbsp;<em>Cell Reports</em></a>&nbsp;that identified vulnerabilities in glioblastoma cancer stem cells that impact their sensitivity to chemotherapy. The next step was to study how vulnerabilities in glioblastoma cancer stem cells vary in a large and diverse set of patient-derived cell lines to identify the most common of these vulnerabilities in each of the subtypes.</p> <p>The team performed screens in glioblastoma stem cell lines from 30 patients, making this the largest screening study of its kind. The patient-derived cell lines were generated by the lab of <strong>Peter Dirks</strong>, chief of the division of neurosurgery at SickKids and a Â鶹ֱ˛Ąapp professor of&nbsp;surgery&nbsp;and&nbsp;molecular genetics in the Temerty Faculty of Medicine. Within the cancer stem cell samples, the team found genes responsible for the proliferation of the two cell subtypes that could be targeted to prevent tumour growth. Combining drugs to target both cell subtypes simultaneously could potentially make for a more effective glioblastoma treatment.</p> <p>“A lot of the research on glioblastoma is conducted with a limited number of immortalized cell lines grown in serum,” said&nbsp;<strong>Fatemeh Molaei</strong>, co-first author on the study and graduate student at the Donnelly Centre and the&nbsp;Leslie Dan Faculty of Pharmacy. “These cells aren’t the best model as they don’t resemble true glioblastoma cells as much as we would like. The findings from our study represent what we see in a patient’s tumour more accurately because our cell lines are derived directly from a large group of patients.&nbsp;</p> <p>“It’s through our screens of this group of cell lines that we were able to identify the OLIG2 and MEK genes as drug targets for the developmental cell subtype and the FAK and B1-Integrin genes as targets for the injury-response subtype.”</p> <p><strong>StĂ©phane Angers</strong>, principal investigator on the study and director of the Donnelly Centre, said&nbsp;it had already been established that there are different subtypes of glioblastoma stem cells, but that their differences are not currently being addressed in the clinic.</p> <p>“In the future, our results will help in designing new treatments that are tailored to patients by targeting the predominant cell subtype, or both subtypes simultaneously,” said Angers, who is also a professor in the&nbsp;Leslie Dan Faculty of Pharmacy&nbsp;and Temerty Faculty of Medicine.&nbsp;“The ability of glioblastoma to adapt to therapeutic treatment is its greatest strength and our biggest challenge. Our study increases our understanding of this type of cancer and proposes a different approach to treating it that will hopefully improve the prognosis of patients.”</p> <p>This research was supported by the Canadian Institutes of Health Research.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Thu, 21 Nov 2024 14:21:00 +0000 Christopher.Sorensen 310649 at Â鶹ֱ˛Ąapp ranked among top 10 universities globally in five subjects: ShanghaiRanking Consultancy /news/u-t-ranked-among-top-10-universities-globally-five-subjects-shanghairanking-consultancy <span class="field field--name-title field--type-string field--label-hidden">Â鶹ֱ˛Ąapp ranked among top 10 universities globally in five subjects: ShanghaiRanking Consultancy</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-11/UofT%20web%20lead%20instructional%20centre.jpg?h=92953138&amp;itok=69sjwe1L 370w, /sites/default/files/styles/news_banner_740/public/2024-11/UofT%20web%20lead%20instructional%20centre.jpg?h=92953138&amp;itok=10s1JT8A 740w, /sites/default/files/styles/news_banner_1110/public/2024-11/UofT%20web%20lead%20instructional%20centre.jpg?h=92953138&amp;itok=1ct7qlka 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-11/UofT%20web%20lead%20instructional%20centre.jpg?h=92953138&amp;itok=69sjwe1L" alt="Students walk through a glass hallway at Â鶹ֱ˛Ąapp Scarborough"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-11-18T15:30:13-05:00" title="Monday, November 18, 2024 - 15:30" class="datetime">Mon, 11/18/2024 - 15:30</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>(photo by Matthew Dochstader/Paradox Images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/mariam-matti" hreflang="en">Mariam Matti</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/global-lens" hreflang="en">Global Lens</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/dalla-lana-school-public-health" hreflang="en">Dalla Lana School of Public Health</a></div> <div class="field__item"><a href="/news/tags/faculty-arts-science" hreflang="en">Faculty of Arts &amp; Science</a></div> <div class="field__item"><a href="/news/tags/global" hreflang="en">Global</a></div> <div class="field__item"><a href="/news/tags/meric-gertler" hreflang="en">Meric Gertler</a></div> <div class="field__item"><a href="/news/tags/rankings" hreflang="en">Rankings</a></div> <div class="field__item"><a href="/news/tags/rotman-school-management" hreflang="en">Rotman School of Management</a></div> <div class="field__item"><a href="/news/tags/shanghai-ranking-consultancy" hreflang="en">Shanghai Ranking Consultancy</a></div> <div class="field__item"><a href="/news/tags/sociology" hreflang="en">Sociology</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The University of Toronto has placed among the top 10 universities globally in five subjects – sociology (2<sup>nd</sup>), medical technology (5<sup>th</sup>), public health (7<sup>th</sup>), finance (8<sup>th</sup>) and management (10<sup>th</sup>) – in the latest ShanghaiRanking Consultancy rankings by subject.</p> <p>Â鶹ֱ˛Ąapp also ranked in the top 100 globally in 42 subjects in the&nbsp;<a href="https://www.shanghairanking.com/rankings/gras/2024" target="_blank">Global Ranking of Academic Subjects 2024</a>, released last week – a feat matched only by the University of Michigan.&nbsp;</p> <p>Among Canadian universities, Â鶹ֱ˛Ąapp ranked first in 27 subjects. That’s more than any other institution.</p> <p>“The University of Toronto’s performance in the latest Shanghai subject rankings underscores our academic excellence across an extremely broad range of fields,” said Â鶹ֱ˛Ąapp President&nbsp;<strong>Meric Gertler</strong>.</p> <p>“These results are a testament to the talent and dedication of our world-leading researchers and scholars.”</p> <p>More than 1,900 universities across 96 countries and regions are listed in the 2024 edition of the Shanghai subject rankings, which cover 55 subjects across natural sciences, engineering, life sciences, medical sciences and social sciences.&nbsp;</p> <p>This year, the methodology was updated with four new indicators, increasing the total to nine. The new evaluation criteria include the number of faculty who are: recipients of significant awards, chief editors of academic journals, leaders in international academic organizations and considered highly cited researchers.&nbsp;</p> <p>Existing criteria continue to assess research output, quality and influence, international collaboration and other academic awards.&nbsp;</p> <p>Of the 55 subject areas covered by the rankings, Â鶹ֱ˛Ąapp ranked in the top 50 globally in 28 subjects and in the top 25 globally in 21 subjects.&nbsp;</p> <p>The updated methodology resulted in significant changes for Â鶹ֱ˛Ąapp in several subjects, including 25 where Â鶹ֱ˛Ąapp moved up the rankings. Notable gains included: chemistry, which moved into 37<sup>th</sup>&nbsp;place from outside the top 50; political science, which climbed 23 spots to 18<sup>th</sup>; biology, which rose 12 spots to 21<sup>st</sup>; human biology, which rose 12 spots to 24<sup>th</sup>; and computer science, which climbed seven places to 17<sup>th</sup>. Â鶹ֱ˛Ąapp declined in 18 subjects and remain unchanged in 5 subjects.&nbsp;</p> <p>The ShanghaiRanking Consultancy also produces the influential Academic Ranking of World Universities, the most recent edition of which <a href="/news/u-t-ranked-1st-canada-26th-globally-shanghairanking-consultancy">ranked&nbsp;Â鶹ֱ˛Ąapp as Canada’s top university&nbsp;and 26<sup>th</sup>&nbsp;in the world</a>.&nbsp;</p> <p>Overall, Â鶹ֱ˛Ąapp continues to be the highest-ranked Canadian university and one of the top-ranked public universities in the five most closely watched international rankings:&nbsp;<em>Times Higher Education’s</em>&nbsp;World University Rankings, QS World University Rankings, ShanghaiRanking Consultancy’s Academic Ranking of World Universities,&nbsp;<em>U.S. News &amp; World Report’s</em>&nbsp;Best Global Universities and National Taiwan University World University Rankings.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Mon, 18 Nov 2024 20:30:13 +0000 Christopher.Sorensen 310653 at Researchers uncover new role for cell’s waste disposal system in spread of pancreatic cancer /news/researchers-uncover-new-role-cell-s-waste-disposal-system-spread-pancreatic-cancer <span class="field field--name-title field--type-string field--label-hidden">Researchers uncover new role for cell’s waste disposal system in spread of pancreatic cancer</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-10/group-pancreatic2.jpg?h=81d682ee&amp;itok=8gpGPZtC 370w, /sites/default/files/styles/news_banner_740/public/2024-10/group-pancreatic2.jpg?h=81d682ee&amp;itok=8iGv4MSx 740w, /sites/default/files/styles/news_banner_1110/public/2024-10/group-pancreatic2.jpg?h=81d682ee&amp;itok=FVxDwrIW 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-10/group-pancreatic2.jpg?h=81d682ee&amp;itok=8gpGPZtC" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-10-22T10:02:57-04:00" title="Tuesday, October 22, 2024 - 10:02" class="datetime">Tue, 10/22/2024 - 10:02</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>Associate Professor Leonardo Salmena, post-doctoral researcher Golam Saffi&nbsp;and former master’s student&nbsp;Lydio To investigated the role of a gene called INPP4B in pancreatic cancer’s ability to spread (supplied images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/betty-zou" hreflang="en">Betty Zou</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/princess-margaret-cancer-centre" hreflang="en">Princess Margaret Cancer Centre</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/university-health-network" hreflang="en">University Health Network</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A preclinical study is revealing new insights into the molecular machinery that drives the aggressiveness of pancreatic cancer.</p> <p>The ability of pancreatic cancer to invade and spread to other parts of the body is a major factor in its poor prognosis, with an overall five-year survival rate of less than 10 per cent.</p> <p>“Pancreatic cancer cells are known to be very metastatic and that’s a big problem,” says&nbsp;<strong>Leonardo Salmena</strong>, an associate professor of&nbsp;pharmacology and toxicology&nbsp;in the University of Toronto’s Temerty Faculty of Medicine.</p> <p>Salmena is the senior author of a study, <a href="https://rupress.org/jcb/article/223/11/e202401012/276895/INPP4B-promotes-PDAC-aggressiveness-via-PIKfyve" target="_blank">published in the<em>&nbsp;Journal of Cell Biology</em></a>,&nbsp;that investigates the role of a gene called INPP4B in pancreatic cancer’s ability to spread. Led by post-doctoral researcher <strong>Golam Saffi</strong>&nbsp;and former master’s student&nbsp;<strong>Lydia To</strong>, the team found that INPP4B exerts its tumour-promoting effects via a cellular organ called the lysosome.</p> <p>“Classically, the lysosome is a garbage disposal organelle where old and tired proteins and other organelles get degraded to be used for energy and other building blocks for the cell,” says Salmena.&nbsp;</p> <p>In most cells, lysosomes typically cluster around the nucleus. But in pancreatic cancer cells, the researchers found that INPP4B drove the lysosomes from the cell interior to the periphery, where these organelles fuse with the cell’s outer membrane. In doing so, the enzymes and other lysosomal factors responsible for breaking down cellular waste are dumped into the space surrounding the tumour cells.&nbsp;</p> <p>This space contains a network of proteins and molecules that provides crucial structural support to cells and tissues while also restricting a cell’s ability to move. The release of the lysosome’s protein-degrading contents into this extracellular space causes the stabilizing network to fall apart, thus making it easier for pancreatic cancer cells to migrate and invade other tissues.</p> <p>Crucially, Salmena and his team also identified the signalling pathway by which INPP4B drives the movement of lysosomes to the cell edge. INPP4B works with two other proteins – PIKfyve and TRPML-1 – to modify the lysosome’s surface structure and alter local calcium levels so that the organelle is propelled to the cell periphery.&nbsp;</p> <p>Based on these findings, the researchers are testing two experimental drugs that target TRPML-1 and PIKfyve in a preclinical model of pancreatic cancer. They are also studying how the release of lysosomal contents can change the immunological environment of the cancer cells, and what effects that might have on the immune system’s ability to respond to the tumour.&nbsp;</p> <p>Salmena first became interested in INPP4B when, during his post-doctoral research, he found that it was involved in breast cancer. Since then, he and his team have shown that the effects of INPP4B vary depending on the context.</p> <p>For example, in some breast cancer types, INPP4B behaves as a tumour suppressor whereas it has an activating role in other aggressive cancers like pancreatic cancer – which the Canadian Cancer Society expects&nbsp;to be the third leading cause of cancer death in Canada in 2024, with an estimated 6,100 people dying from the disease.&nbsp;</p> <p>Salmena and his colleagues later showed that among all cancers, INPP4B levels are highest in pancreatic tumours, and that high levels of the protein are associated with decreased overall survival in people with pancreatic cancer.</p> <p>The study was a collaboration between Salmena’s group,&nbsp;<strong>Roberto Botelho</strong>, a professor of chemistry and biology at Toronto Metropolitan University, and&nbsp;<strong>Steven Gallinger</strong>, a hepatobiliary and pancreatic surgical oncologist and clinician-scientist at&nbsp;Princess Margaret Cancer Centre, University Health Network and&nbsp;a professor of&nbsp;surgery&nbsp;and&nbsp;laboratory medicine and pathobiology&nbsp;in Temerty Medicine. He is also director of the PanCuRx Translational Research Initiative at the Ontario Institute for Cancer Research.</p> <p>The study was supported by the Cancer Research Society and the Canadian Institutes of Health Research.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Tue, 22 Oct 2024 14:02:57 +0000 Christopher.Sorensen 310033 at Growing up with a dog may be good for your gut health: Study /news/growing-dog-may-be-good-your-gut-health-study <span class="field field--name-title field--type-string field--label-hidden">Growing up with a dog may be good for your gut health: Study</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-09/GettyImages-1395719605-crop.jpg?h=81d682ee&amp;itok=I9qLxy8N 370w, /sites/default/files/styles/news_banner_740/public/2024-09/GettyImages-1395719605-crop.jpg?h=81d682ee&amp;itok=ueHimtCu 740w, /sites/default/files/styles/news_banner_1110/public/2024-09/GettyImages-1395719605-crop.jpg?h=81d682ee&amp;itok=rN9vIX42 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-09/GettyImages-1395719605-crop.jpg?h=81d682ee&amp;itok=I9qLxy8N" alt="a young boy with a dog lying down in a field"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-09-26T10:44:39-04:00" title="Thursday, September 26, 2024 - 10:44" class="datetime">Thu, 09/26/2024 - 10:44</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>Living with a dog between ages five and 15 is associated with reduced risk of developing Crohn’s disease, according to new research from Sinai Health and Â鶹ֱ˛Ąapp (photo by&nbsp;Kseniya Starkova/Getty Images)&nbsp;</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jovana-drinjakovic" hreflang="en">Jovana Drinjakovic</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/department-immunology" hreflang="en">Department of Immunology</a></div> <div class="field__item"><a href="/news/tags/department-medicine" hreflang="en">Department of Medicine</a></div> <div class="field__item"><a href="/news/tags/sinai-health" hreflang="en">Sinai Health</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/lunenfeld-tanenbaum-research-institute" hreflang="en">Lunenfeld-Tanenbaum Research Institute</a></div> <div class="field__item"><a href="/news/tags/mount-sinai-hospital" hreflang="en">Mount Sinai Hospital</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">Research from Sinai Health and Â鶹ֱ˛Ąapp found early exposure to dogs is linked to a healthier gut and reduced risk of developing Crohn's disease</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Dog lovers can attest to the range of benefits that come with having a canine companion, but improved gut health likely isn’t one of them.</p> <p>That may be about to change following research from Sinai Health and the University of Toronto that&nbsp;shows exposure to dogs during childhood is linked to beneficial changes in gut bacteria, gut permeability and blood biomarkers.</p> <p>The study, <a href="https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1542356524004506?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1542356524004506%3Fshowall%3Dtrue&amp;referrer=https:%2F%2Fwww.researchgate.net%2F">published in&nbsp;<em>Clinical Gastroenterology and Hepatology</em></a>, found living with a dog between ages five and 15 is associated with a healthier gut microbiome and reduced risk of developing Crohn’s disease.</p> <p>The research shines new light on how environmental factors influence the onset of Crohn’s – an inflammatory bowel condition – and could inform future prevention strategies.</p> <p>For the study, researchers led by <strong>Kenneth Croitoru</strong> and <strong>Williams Turpin</strong> of Mount Sinai Hospital’s <a href="https://www.sinaihealth.ca/areas-of-care/inflammatory-bowel-disease">Centre for Inflammatory Bowel Disease (IBD)</a> investigated how dozens of environmental factors impact the likelihood of developing Crohn’s as part of their overarching effort to be able to predict those at risk and potentially intervene early.</p> <p>“The idea behind predicting someone's risk of disease is that you can then also begin to understand who you might want to do something to try and prevent disease,” says Croitoru, a clinician-scientist at the&nbsp;Lunenfeld-Tanenbaum Research Institute&nbsp;(LTRI), part of&nbsp;Sinai Health, and a professor of medicine and immunology at Â鶹ֱ˛Ąapp’s Temerty Faculty of Medicine.</p> <p>Croitoru notes the study doesn’t reveal why living with a dog makes someone less prone to Crohn’s disease. “We have established associations between environmental factors and Crohn’s and are now trying to understand how these environmental factors affect the triggering of the disease,” says Croitoru, who is also a gastroenterologist at Mount Sinai Hospital.</p> <p>The study also found living with a large-sized family in the first year of life to reduce the likelihood of getting Crohn’s. It also found people who lived with a bird at the time of study were more likely to develop the disease.</p> <p>Caused by inflammation in the gastrointestinal tract, Crohn’s disease can have far-reaching consequences on overall health and well-being. Its incidence among children under 10 has doubled since 1995, while the annual cost of inflammatory bowel disease to Canada is estimated at $5.4 billion per year, according to Crohn’s and Colitis Canada, a national non-profit.</p> <p>The likelihood of getting Crohn’s is strongly influenced by genetics, but the environment also plays a role, says Croitoru, who holds the Canada Research Chair in Inflammatory Bowel Diseases. While we can’t change our genes, we can modify our surroundings and diet, for example, to potentially prevent the disease from occurring.</p> <p>These findings come from the <a href="https://www.gemproject.ca/">Genetic, Environmental and Microbial (GEM) Project</a>, the largest study of its kind that seeks to identify potential triggers of Crohn’s disease.</p> <p>Coordinated at Mount Sinai Hospital since 2008, the GEM Project has been collecting comprehensive medical and lifestyle data from over 5,000 healthy first-degree relatives of people who have Crohn’s and come from all over the world, including Australia, Canada, Israel, New Zealand, the U.K. and the U.S.</p> <p>The project is funded by Crohn’s and Colitis Canada, the Canadian Institutes of Health Research and the Helmsley Charitable Foundation.</p> <p>In the 15 years since the study began, over 120 people have developed the disease. “By understanding what is different about those who develop the disease, we should be able to predict who is at risk,” says Croitoru.</p> <p>Previously, the group <a href="https://www.sinaihealth.ca/news/canadian-researchers-have-discovered-gut-bacteria-that-may-lead-to-crohns-disease/">identified&nbsp;differences in the microbiome and other biomarkers</a> in people who go on to develop Crohn’s and those who don’t.</p> <p>In another recent report published in&nbsp;Gastroenterology,&nbsp;<strong>Sun-Ho Lee</strong>, a clinician-scientist at Mount Sinai Hospital’s IBD Centre and an assistant professor at the&nbsp;Institute of Medical Science&nbsp;at Temerty Medicine, used available data and machine learning to develop an “<a href="https://www.gastrojournal.org/article/S0016-5085(24)05401-5/fulltext">integrative risk score</a>” that predicts the risk of Crohn’s with a high degree of accuracy.</p> <p>But risk prediction is only the first step, says Croitoru, whose ultimate goal is to be able to intervene and prevent the disease from starting.</p> <p>He and his team are now conducting research that seeks to devise and test strategies for prevention by, for example, adding supplements to the diet to promote a healthy microbiome.</p> <p>“Sinai Health is committed to groundbreaking research and bringing those discoveries to patients," said&nbsp;<strong>Anne-Claude Gingras</strong>, director of LTRI and vice-president of research at Sinai Health.</p> <p>“By integrating genetic, environmental, and microbial data, Dr. Croitoru and colleagues are paving the way towards personalized intervention strategies that could significantly reduce the incidence of Crohn’s disease.”</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Thu, 26 Sep 2024 14:44:39 +0000 rahul.kalvapalle 309604 at AI tool reduces risk of unexpected hospital deaths by 26 per cent: Study /news/ai-tool-reduces-risk-unexpected-hospital-deaths-26-cent-study <span class="field field--name-title field--type-string field--label-hidden">AI tool reduces risk of unexpected hospital deaths by 26 per cent: Study</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-09/GettyImages-1217096086-crop.jpg?h=81d682ee&amp;itok=n6CofzDF 370w, /sites/default/files/styles/news_banner_740/public/2024-09/GettyImages-1217096086-crop.jpg?h=81d682ee&amp;itok=DTWrdmmR 740w, /sites/default/files/styles/news_banner_1110/public/2024-09/GettyImages-1217096086-crop.jpg?h=81d682ee&amp;itok=_S-xmC-1 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-09/GettyImages-1217096086-crop.jpg?h=81d682ee&amp;itok=n6CofzDF" alt="A female doctor checks a computer screen next to a patient in a hospital"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-09-23T12:50:13-04:00" title="Monday, September 23, 2024 - 12:50" class="datetime">Mon, 09/23/2024 - 12:50</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>(photo by Tempura/Getty Images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/adam-miller" hreflang="en">Adam Miller</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/unity-health" hreflang="en">Unity Health</a></div> <div class="field__item"><a href="/news/tags/artificial-intelligence" hreflang="en">Artificial Intelligence</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/st-michael-s-hospital" hreflang="en">St. Michael's Hospital</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">CHARTWatch, an artificial intelligence early warning system developed at&nbsp;Unity Health Toronto,&nbsp;alerts physicians when hospital patients face a high risk of unexpected death or transfer to an ICU</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A new study by Toronto researchers evaluates the use of&nbsp;<a href="https://unityhealth.to/2024/07/innovating-care-experience-with-ai/" target="_blank">CHARTWatch</a>, an artificial intelligence early warning system developed at&nbsp;Unity Health Toronto&nbsp;that monitors hospitalized patients in real-time, identifies those at high risk of unexpected death or transfer to an intensive care unit, and alerts doctors and nurses to intervene early.</p> <p>The&nbsp;study, <a href="https://www.cmaj.ca/content/196/30/E1027" target="_blank">published in the&nbsp;<em>Canadian Medical Association Journal</em></a>, shows a 26 per cent reduction in unanticipated mortality after the tool was implemented in the general internal medicine ward of&nbsp;Unity Health Toronto’s St. Michael’s Hospital.</p> <p>“As AI tools are increasingly being used in medicine, it is important that they are evaluated carefully to ensure that they are safe and effective,” says lead author&nbsp;<strong>Amol Verma</strong>, general internist at Unity Health and professor in the&nbsp;department of medicine&nbsp;in the University of Toronto’s Temerty Faculty of Medicine who led the development and implementation of CHARTWatch.</p> <figure role="group" class="caption caption-drupal-media align-left"> <div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/2024-09/Verma-Mamdani-crop.jpg" width="350" height="233" alt="&quot;&quot;"> </div> </div> <figcaption><em>Amol Verma (L) and Muhammad Mamdani (supplied images)</em></figcaption> </figure> <p>“Our findings suggest that AI-based early warning systems are promising for reducing unexpected deaths in hospitals.”</p> <p>One of the primary sources of unplanned admission to the ICU is the unexpected deterioration of hospitalized patients, which prompted the research team to develop this AI tool and study its effectiveness.&nbsp;</p> <p>“This important study evaluates the outcomes associated with the complex deployment of the entire AI solution, which is critical to understanding the real-world impacts of this promising technology,” says study co-author&nbsp;<strong>Muhammad Mamdani</strong>, vice president of data science and advanced analytics at Unity Health and director of Â鶹ֱ˛Ąapp’s Temerty Centre for Artificial Intelligence Research and Education in Medicine.</p> <p>“We hope other institutions can learn from and improve upon Unity Health Toronto’s experiences to benefit the patients they serve.”&nbsp;</p> <p>The study analyzed data from 13,649 patients aged 55 to 80 years old admitted to the general internal medicine unit (9,626 in the pre-intervention period and 4,023 using CHARTWatch) and 8,470 admitted to subspeciality units that did not use CHARTWatch.</p> <h4>Helping to prioritize patient needs</h4> <p>“The CHARTWatch project started at Unity Health when we asked patients, clinicians, hospital leaders, what would you want to use artificial intelligence for? If you could predict one thing that AI would tell you, what should that be?” says Verma, who is also&nbsp;the Temerty Professor of AI Research and Education in Medicine.</p> <p>“And one of the leading priorities of everyone was to be able to predict in advance which patients might become so sick in hospital that they need ICU or might die.”&nbsp;</p> <p>During the 19-month-long intervention period, 482 patients in the general internal medicine became high-risk, compared with 1,656 patients who became high risk in the 43-month-long pre-intervention period. There were also fewer non-palliative deaths in the CHARTWatch group than in the pre-intervention group (1.6 per cent versus 2.1 per cent).&nbsp;</p> <p>“If I were a patient, I would be so relieved to know that we have this kind of system,” said co-author&nbsp;<strong>Yuna Lee</strong>, division head and general internist at St. Michael’s and professor in the department of medicine at Â鶹ֱ˛Ąapp.</p> <p>“So, when the patient gets a high-risk alert, they’re going to be assessed by senior staff right away. Also, they’re going to have quite close monitoring by nursing staff, so they check on them every one to two hours.”</p> <h4>Expanding the impact of CHARTWatch</h4> <p>CHARTWatch inputs more than 100 aspects of a patient’s medical history and current health status that are routinely stored in the hospital’s electronic medical record. It analyzes the interactions between these inputs and how they change over time. With that information, it’s able to categorize each patient by their risk for deterioration and send an alert to prioritize treatment.</p> <p>The study is one of the first to evaluate how CHARTWatch can benefit hospital patients in Canada and shows the potential real-world impact of AI on the health-care sector.&nbsp;<strong>Damian Jankowicz</strong>, Unity Health’s vice-president and chief information and AI officer, says he hopes AI tools such as CHARTWatch will continue to have a profound impact on patients.&nbsp;</p> <p>“Hopefully with reduced administrative burden on our providers, they will have more time to spend with our patients and really focus on the patient needs,” he says.&nbsp;</p> <p>“I hope that AI will be able to distill the incredible amounts of information that’s coming at our clinicians&nbsp;into important components and really bring their clinical judgment to the forefront.”</p> <p><em>This story first was&nbsp;<a href="http://unityhealth.to/2024/09/ai-tool-study/" target="_blank">first published&nbsp;by Unity Health</a>.</em></p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Mon, 23 Sep 2024 16:50:13 +0000 Christopher.Sorensen 309507 at